Liver Protection
Numerous animal studies have demonstrated that the active biochemicals of Picrorhiza kurrooa are effective at preventing liver toxicity--in fact, showed significant curative activity--vis-à-vis numerous toxic agents such as galactosamine, thiocetamide, and carbon tetrachloride. When administered, the toxic agents produced a 40-62% inhibition of cell viability. On removal of the toxic agents and the addition of the Picrorhiza extract, a concentration dependent reversal of these negative effects was seen in as little as 48 hours. A similar effect was seen when oral Picrorhiza extract was administered to rats poisoned by aflatoxin B1 exposure. Picrorhiza kurrooa "significantly prevented the biochemical changes induced by aflatoxin B1."
Now, while it is true that most of us are not too worried by things like hepatitis, cirrhosis, or ingesting carbon tetrachloride, we still subject our livers to constant stressors that ultimately damage and destroy liver cells—and, remember, that damage is cumulative over time. We're talking about things like:
Too much protein in the diet. Protein metabolism is especially taxing on the liver since it is the liver, which must metabolize complex proteins into simple compounds. The greater the consumption of protein, the greater the stress on the liver.
Too many simple carbohydrates in the diet. The body converts excess simple carbohydrates into triglycerides, which are then stored in the liver as fat. The more fat stored in the liver, the harder it is for the liver to perform its full range of normal functions.
Overeating. Too much enzyme-deficient food stresses the liver.
Drug residues. Virtually all of the drugs that we take (medicinal and recreational) are processed, purified, and refined in the liver—in preparation for elimination from the body.
Vitamin isolates. Many vitamins in their isolated form are toxic to the body and must be conjugated by the liver to render them harmless and make them available to the cells. Every time you supplement with such vitamins, you stress the liver.
Cirrhosis aside, any consumption of alcohol causes inflammation of the liver's tissue. Once the liver is inflamed, it can no longer filter, which causes it to plug up with fat and become even more inflamed. If we consume enough alcohol, we overwhelm the liver's ability to regenerate itself, and the net result is cirrhosis (or hardening) of the liver.
Toxins, heavy metals, and pesticides. Everything we breathe, eat, and absorb through our skin is purified and refined in the liver.
Lack of exercise forces the liver to do the elimination work that should be done by the lungs and the skin.
Thus, any herbs that are hepaprotective and that promote liver regeneration are an essential component of any health regimen.
Liver Regeneration
Similar to milk thistle, Picrorhiza has been shown to stimulate liver regeneration in rats. Specifically, studies have shown that oral administration of picroliv, a standardized fraction of roots and rhizomes of Picrorhiza kurrooa, showed stimulation of nucleic acid and protein synthesis in rat livers. Results are comparable to those seen when silymarin is administered. Even better. Picrorhiza extract was also shown to be effective in reversing alcohol-induced liver damage in rats. Treatment restored the damage in a dose-dependent manner (36-100%) over 45 days. This is significant for anyone suffering from cirrhosis.
Viral Hepatitis
Studies indicate that Picrorhiza extracts appear to be of therapeutic value in treating viral hepatitis. An in vitro study investigated anti-hepatitis B-like activity of Picrorhiza and found it to have promising anti-hepatitis B surface antigen activity. In addition, in a randomized, double-blind, placebo-controlled trial of 33 patients diagnosed with acute viral hepatitis, 375 mg of Picrorhiza root powder was given three times daily for two weeks to 15 of the patients, while the remaining 18 patients acted as controls and received a placebo. Bilirubin, SGOT, and SGPT values were significantly lower in the treatment group (that's a good thing), and the time required for bilirubin values to drop to 2.5 mg % was 27.4 days in the treatment group versus 75.9 days for the placebo group.
Cancer
As mentioned earlier, Picrorhiza has also demonstrated cancer protective properties. When tested against human breast cancer cells and human prostate cancer cells, Picrorhiza extracts exhibited promising antioxidant potentials and were also observed to be cytotoxic at the tested dosage and were able to target the cancer cells and kill them. In yet another study, Picrorhiza extracts demonstrated chemoprotective potential against chemically-induced liver tumors and induced sarcoma tumors and chemically-initiated papilloma formations.
The bottom line is Picrorhiza kurrooa extract has incredible liver protective and regenerative capabilities. In this case, the whole is greater than the sum of its parts. And again, most of us are not dealing with the extreme circumstances covered in the studies, but what those studies tell us is that Picrorhizza is a mandatory ingredient for protecting our livers against the cumulative assaults of daily life.
References:
Jonbarron.org
-http://www.ncbi.nlm.nih.gov/pubmed/10334634
- http://www.ncbi.nlm.nih.gov/pubmed/11169162
- http://www.ncbi.nlm.nih.gov/pubmed/1506022
- http://www.ncbi.nlm.nih.gov/pubmed/10473171
- http://www.ncbi.nlm.nih.gov/pubmed/2370093
- http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1996;volume=42;issue=4;spage=105;epage=8;aulast=Vaidya
- http://www.ncbi.nlm.nih.gov/pubmed/21081148
- http://www.ncbi.nlm.nih.gov/pubmed/11277323
- http://www.ncbi.nlm.nih.gov/pubmed/11406836
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